Peroxynitrite mediates disruption of Ca2+ homeostasis by carbon monoxide via Ca2+ ATPase degradation

Hettiarachchi, N. T., Boyle, J. P., Bauer, C. C., Dallas, M. L. ORCID: https://orcid.org/0000-0002-5190-0522, Pearson, H. A., Hara, S., Gamper, N. and Peers, C. (2012) Peroxynitrite mediates disruption of Ca2+ homeostasis by carbon monoxide via Ca2+ ATPase degradation. Antioxidants & Redox Signaling, 17 (5). pp. 744-755. ISSN 1523-0864

Abstract/Summary

CO stimulates formation of NO and reactive oxygen species which, via peroxynitrite formation, inhibit Ca(2+) extrusion via PMCA, leading to disruption of Ca(2+) signaling. We propose this contributes to the neurological damage associated with CO toxicity.