Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R. ORCID: https://orcid.org/0000-0002-0566-0476, Gibson, G. ORCID: https://orcid.org/0000-0002-0566-0476, Jia, W. and Petttersen, S. (2012) Host-gut microbiota metabolic interactions. Science, 336 (6086). pp. 1262-1267. ISSN 1095-9203 doi: 10.1126/science.1223813

Abstract/Summary

The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/28078
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group
Publisher	American Association for the Advancement of Science
Download/View statistics	View download statistics for this item