Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques

Ahmed, A., Barry, B. W., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 and Davis, A. F. (2004) Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques. Journal of Pharmaceutical and Biomedical Analysis, 34. pp. 945-956. ISSN 0731-7085 doi: 10.1016/j.jpba.2003.11.018

Abstract/Summary

The solubility of penciclovir (C10N5O3H17) in a novel film formulation designed for the treatment of cold sores was determined using X-ray, thermal, microscopic and release rate techniques. Solubilities of 0.15–0.23, 0.44, 0.53 and 0.42% (w/w) resulted for each procedure. Linear calibration lines were achieved for experimentally and theoretically determined differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD) data. Intra- and inter-batch data precision values were determined; intra values were more precise. Microscopy was additionally useful for examining crystal shape, size distribution and homogeneity of drug distribution within the film. Whereas DSC also determined melting point, XRPD identified polymorphs and release data provided relevant kinetics.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/27357
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	Elsevier
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