Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages

Buckingham, J., Sabbagh, G., Brazier, J., Fisher, J. and Cosstick, R. (2005) Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages. Nucleosides, Nucleotides & Nucleic Acids, 24 (5-7). pp. 491-495. ISSN 1532-2335 doi: 10.1081/NCN-200061776

Abstract/Summary

An in-depth study into the incorporation of multiple 3'-S-phosphorothiolate modifications into oligodeoxynucleotides (ODNs) and their subsequent effect on ODN/DNA and ODN/RNA duplex stability. 3'-S-Phosphorothiolate linkages increase the stability of ODN/RNA duplexes and decrease the stability of ODN/DNA duplexes.