Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

Madine, J., Davies, H. A., Shaw, C., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926 and Middleton, D. A. (2012) Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks. Chemical Communications, 48. pp. 2976-2978. ISSN 1359-7345 doi: 10.1039/C2CC17118J

Abstract/Summary

The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/27174
Identification Number/DOI	10.1039/C2CC17118J
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
Publisher	The Royal Society of Chemistry
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