Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating bioactivity to self-assembly

Castelletto, V., Cheng, G. and Hamley, I. ORCID: https://orcid.org/0000-0002-4549-0926 (2011) Amyloid peptides incorporating a core sequence from the amyloid beta peptide and gamma amino acids: relating bioactivity to self-assembly. Chemical Communications, 47. pp. 12470-12472. ISSN 1359-7345 doi: 10.1039/c1cc15493a

Abstract/Summary

A series of heptapeptides comprising the core sequence Ab(16–20), KLVFF, of the amyloid b peptide coupled with paired N-terminal c-amino acids are investigated in terms of cytotoxicity reduction and binding to the full Ab peptide, both pointing to inhibition of fibrillisation for selected compounds. This is related to the self-assembly capacity of the heptapeptides.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/24933
Identification Number/DOI	10.1039/c1cc15493a
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Electron Microscopy Laboratory (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	Royal Society of Chemistry
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