Relatedness testing in subdivided populations

Ayres, K. L. (2000) Relatedness testing in subdivided populations. Forensic Science International, 114 (2). pp. 107-115. ISSN 0379-0738 doi: 10.1016/S0379-0738(00)00289-9

Abstract/Summary

Assigning probabilities to alleged relationships, given DNA profiles, requires, among other things, calculation of a likelihood ratio (LR). Such calculations usually assume independence of genes: this assumption is not appropriate when the tested individuals share recent ancestry due to population substructure. Adjusted LR formulae, incorporating the coancestry coefficient F(ST), are presented here for various two-person relationships, and the issue of mutations in parentage testing is also addressed.