The cell cycle and drug discovery: The promise and the hope

Brooks, G. and La Thangue, N.B. (1999) The cell cycle and drug discovery: The promise and the hope. Drug Discovery Today, 4 (10). pp. 455-463. ISSN 1359-6446 doi: 10.1016/S1359-6446(99)01400-2

Abstract/Summary

In recent years, there have been major developments in the understanding of the cell cycle. It is now known that normal cellular proliferation is tightly regulated by the activation and deactivation of a series of proteins that constitute the cell cycle machinery. The expression and activity of components of the cell cycle can be altered during the development of a variety of diseases where aberrant proliferation contributes to the pathology of the illness. Apart from yielding a new source of untapped therapeutic targets, it is likely that manipulating the activity of such proteins in diseased states will provide an important route for treating proliferative disorders, and the opportunity to develop a novel class of future medicines.