Development of new methodologies for entry to targets of therapeutic interest

Osborn, H.M.I. ORCID: https://orcid.org/0000-0002-0683-0457 (2005) Development of new methodologies for entry to targets of therapeutic interest. Synlett (17). pp. 2571-2586. ISSN 0936-5214 doi: 10.1055/s-2005-917076

Abstract/Summary

This Account provides an overview of strategies that have been reported from our laboratories for the synthesis of targets of therapeutic interest, namely carbohydrates, and prodrugs for the treatment of melanoma. These programmes have involved the development of new synthetic methodologies including the regio- and stereoselective synthesis of specific carbohydrate isomers, and new protecting group methodologies. This review provides an insight into the progress of these research themes, and suggests some applications for the targets that are currently being explored.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/13670
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy
Uncontrolled Keywords	carbohydrates, prodrugs, regioselective, stereoselective, melanoma, LIPASE-CATALYZED ACYLATION, DIRECT CHEMICAL-SYNTHESIS, ALPHA-LINKED, GLCNAC, ONE-POT SYNTHESIS, ANOMERIC SUBSTITUENTS, MALIGNANT-MELANOMA, GLYCOSIDASE INHIBITORS, ESCHERICHIA-COLI, REGIOSELECTIVE, C-3-O-ACYLATION, PROTECTING GROUPS
Download/View statistics	View download statistics for this item