Genistein reverses changes of the proteome induced by oxidized-LDL in EA center dot hy 926 human endothelial cells

Fuchs, D., Erhard, P., Turner, R., Rimbach, G., Daniel, H. and Wenzel, U. (2005) Genistein reverses changes of the proteome induced by oxidized-LDL in EA center dot hy 926 human endothelial cells. Journal of Proteome Research, 4 (2). pp. 369-376. ISSN 1535-3893 doi: 10.1021/pr049820r

Abstract/Summary

Endothelial cells are primary targets for pro-atherosclerotic stressors such as oxidized LDL (ox-LDL). The isoflavone genistein, on the other hand, is suggested to prevent a variety of processes underlying atherosclerosis and cardiovascular diseases. By analyzing the proteome of EA(.)hy 926 endothelial cells, here we show, that genistein reverses the ox-LDL-induced changes of the steady-state levels of several proteins involved in atherosclerosis. These alterations caused by genistein are functionally linked to the inhibition of ox-LDL induced apoptosis.