Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender

Olano-Martin, E., Abraham, E. C., Gill-Garrison, R., Valdes, A. M., Grimaldi, K., Tang, F., Jackson, K. G. ORCID: https://orcid.org/0000-0002-0070-3203, Williams, C. M. and Minihane, A. M. (2008) Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender. Journal of Lipid Research, 49 (5). pp. 945-953. ISSN 0022-2275 doi: 10.1194/jlr.M700112-JLR200

Abstract/Summary

Although apolipoprotein AN (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender X genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males. Lower HDL-cholesterol was associated with the rare TC genotype (P = 0.047). Significant linkage disequilibrium was found between the apoA-V -1131 T>C and the apoC-III 3238 C>G variants, with univariate analysis indicating an impact of this apoC-III single nucleotide polymorphism (SNP) on TG AUC (P = 0.015). However, in linear regression analysis, a significant independent association with TG AUC (P = 0.007) was only evident for the apoA-V -1131 T>C SNP, indicating a greater relative importance of the apoA-V genotype.