Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols

Vauzour, D., Vafeiadou, K. and Spencer, J. P. E. ORCID: https://orcid.org/0000-0003-2931-7274 (2007) Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols. Biochemical and Biophysical Research Communications, 362 (2). pp. 340-346. ISSN 0006-291X doi: 10.1016/j.bbrc.2007.07.153

Abstract/Summary

The death of nigral neurons in Parkinson's disease is thought to involve the formation of the endogenous neurotoxin, 5-S-cysteinyl-dopamine. In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-eysteinyl-dopamine via their capacity to undergo tyro sina se-induced oxidation to yield cysteinyl-polyphenol adducts. In contrast, the inhibition afforded by the flavanone, hesperetin, was not accompanied by the formation of cysteinyl-hesperetin adducts, indicating that it may inhibit via direct interaction with tyrosinase. Whilst the stilbene resveratrol also inhibited 5-S-eysteinyl-dopamine formation, this was accompanied by the formation of dihydrobenzothiazine, a strong neurotoxin. Our data indicate that the inhibitory effects of polyphenols against 5-S-cysteinyl-dopamine formation are structure-dependent and shed further light on the mechanisms by which polyphenols exert protection against neuronal injury relevant to neurodegenerative diseases. (C) 2007 Elsevier Inc. All rights reserved.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/12895
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Uncontrolled Keywords	5-s-cysteinyl-dopamine, tyrosinase, neurodegeneration, Parkinson, disease, catechin, hesperetin, caffeic acid, resveratrol, PARKINSONS-DISEASE, MUSHROOM TYROSINASE, OXIDATIVE PATHWAYS, CATECHOLAMINES, BRAIN, 5-S-CYSTEINYLDOPAMINE, (-)-EPIGALLOCATECHIN-3-GALLATE, METABOLITES, MECHANISMS, FLAVONOIDS
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