Development of mucoadhesive vaginal films for metronidazole delivery Using methacryloylated, crotonoylated, and itaconoylated gelatin blends with poly(vinyl alcohol)

Shatabayeva, E. O., Kaldybekov, D. B., Kenessova, Z. A., Tuleyeva, R. N., Kudaibergenov, S. E. and Khutoryanskiy, V. V. ORCID: https://orcid.org/0000-0002-7221-2630 (2025) Development of mucoadhesive vaginal films for metronidazole delivery Using methacryloylated, crotonoylated, and itaconoylated gelatin blends with poly(vinyl alcohol). AAPS PharmSciTech, 26 (2). 63. ISSN 1530-9932 doi: 10.1208/s12249-025-03055-1

Abstract/Summary

Purpose This work reports the development and characterisation of polymeric films composed of gelatin or its chemically modified derivatives (crotonoylated, itaconoylated, and methacryloylated gelatins) blended with polyvinyl alcohol (PVA). Metronidazole served as an antimicrobial drug in these formulations. Methods The films were produced by casting aqueous solutions of polymers, followed by solvent evaporation. Their structure and physicochemical characteristics were studied using Fourier transform infrared spectroscopy, scanning electron microscopy, and mechanical testing. The thickness of the films, their folding endurance, the surface pH, and transparency were also evaluated. The mucoadhesive performance of the films was evaluated through an ex vivo detachment technique involving freshly excised sheep vaginal tissues. In vitro cumulative drug release studies were conducted using Franz diffusion cells. Results The results demonstrate that incorporating unsaturated functional groups into gelatin improves its mucoadhesive properties compared to native gelatin. The drug release experiments conducted in vitro showed that the cumulative release from pure gelatin/PVA films was found to be 49 ± 2%, whereas modified gelatins/PVA (70:30) films released ~ 64–71%.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/120938
Identification Number/DOI	10.1208/s12249-025-03055-1
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	Springer
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