Hebbian plasticity induced by temporally coincident BCI enhances post-stroke motor recovery

Krueger, J., Krauth, R., Reichert, C., Perdikis, S. ORCID: https://orcid.org/0000-0003-2033-2486, Vogt, S., Huchtemann, T., Dürschmid, S., Sickert, A., Lamprecht, J., Huremovic, A., Görtler, M., Nasuto, S. J. ORCID: https://orcid.org/0000-0001-9414-9049, Tsai, I.-C., Knight, R. T., Hinrichs, H., Heinze, H.-J., Lindquist, S., Sailer, M., Millán, J. d. R. and Sweeney-Reed, C. M. ORCID: https://orcid.org/0000-0002-3684-1245 (2024) Hebbian plasticity induced by temporally coincident BCI enhances post-stroke motor recovery. Scientific Reports, 14. 18700. ISSN 2045-2322 doi: 10.1038/s41598-024-69037-8

Abstract/Summary

Functional electrical stimulation (FES) can support functional restoration of a paretic limb post-stroke. Hebbian plasticity depends on temporally coinciding pre- and post-synaptic activity. A tight temporal relationship between motor cortical (MC) activity associated with attempted movement and FES-generated visuo-proprioceptive feedback is hypothesized to enhance motor recovery. Using a brain–computer interface (BCI) to classify MC spectral power in electroencephalographic (EEG) signals to trigger FES-delivery with detection of movement attempts improved motor outcomes in chronic stroke patients. We hypothesized that heightened neural plasticity earlier post-stroke would further enhance corticomuscular functional connectivity and motor recovery. We compared subcortical non-dominant hemisphere stroke patients in BCI-FES and Random-FES (FES temporally independent of MC movement attempt detection) groups. The primary outcome measure was the Fugl-Meyer Assessment, Upper Extremity (FMA-UE). We recorded high-density EEG and transcranial magnetic stimulation-induced motor evoked potentials before and after treatment. The BCI group showed greater: FMA-UE improvement; motor evoked potential amplitude; beta oscillatory power and long-range temporal correlation reduction over contralateral MC; and corticomuscular coherence with contralateral MC. These changes are consistent with enhanced post-stroke motor improvement when movement is synchronized with MC activity reflecting attempted movement.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/120556
Identification Number/DOI	10.1038/s41598-024-69037-8
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences > Department of Bio-Engineering
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