Anti-leishmanial study of discrete tetrahedral zinc(ii) β-oxodithioester complexes

Yadav, C. L. ORCID: https://orcid.org/0000-0003-1535-5018, Anamika ORCID: https://orcid.org/0000-0001-8070-710X, Singh, R., Kumar, A. ORCID: https://orcid.org/0000-0001-5541-6191, Singh, R. K. ORCID: https://orcid.org/0000-0003-0977-1461, Drew, M. G. B. ORCID: https://orcid.org/0000-0001-8687-3440, Manar, K. K. ORCID: https://orcid.org/0000-0002-5668-9367 and Singh, N. ORCID: https://orcid.org/0000-0003-1578-5456 (2025) Anti-leishmanial study of discrete tetrahedral zinc(ii) β-oxodithioester complexes. New Journal of Chemistry, 49 (2). pp. 484-496. ISSN 1369-9261 doi: 10.1039/d4nj04275a

Abstract/Summary

We have synthesized four new oxygen/sulfur(O^S) chelate complexes, [Zn(L)2], where L represents different ligands: methyl-3-hydroxy-3-(furyl)-2-propenedithioate (L1, 1), methyl-3-hydroxy-3-(p-fluorophenyl)-2-propenedithioate (L2, 2), methyl-3-hydroxy-3-(p-chlorophenyl)-2-propenedithioate (L3, 3), and methyl-3-hydroxy-3-(p-bromophenyl)-2-propenedithioate (L4, 4). These complexes have been characterized by using IR, multinuclear NMR (1H, 13C{1H}, and 19F{1H}), and UV-vis spectroscopy. The structural characterization of complexes 1, 2, and 4 was further achieved by single crystal X-ray diffraction (SCXRD). The supramolecular structures of these complexes are stabilized by non-covalent C–H⋯π (ZnOSC3, chelate), C–S⋯π (ZnOSC3, chelate), π⋯π (ZnOSC3,), C–H⋯O, C–H⋯F–C and C–H⋯H–C interactions. The luminescence properties of Zn(II) complexes 1–4 were studied at room temperature in the solid phase. The antileishmanial activity was evaluated for all complexes. Complexes 1 and 4 exhibited significant anti-promastigote and anti-amastigote activities, with IC50 values of 2.0 and 1.33 μg mL−1, and 2.79 and 2.02 μg mL−1, respectively. Additionally, cytotoxicity assays demonstrated that these Zn(II) β-oxodithioester complexes were toxic to promastigotes, but showed reduced toxicity towards RAW 264.7 cell lines at varying concentrations. Furthermore, the optical band gap energies of complexes 1–4 were measured and found to exhibit semiconducting behavior.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/119952
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	Royal Society of Chemistry (RSC)
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