Psilocybin as a novel treatment for chronic pain

Askey, T., Lasrado, R., Maiaru, M. ORCID: https://orcid.org/0000-0003-0927-6567 and Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238 (2024) Psilocybin as a novel treatment for chronic pain. British Journal of Pharmacology. ISSN 0007-1188 doi: 10.1111/bph.17420

Abstract/Summary

Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti-nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co-morbid with pain. This review primarily explores the utility of preclinical animal models in investigating the potential of psilocybin as an anti-nociceptive agent. Initial studies involving psilocybin in animal models of neuropathic and inflammatory pain are summarised, alongside areas where further research is needed. The potential mechanisms of action, includ- ing targeting serotonergic pathways through the activation of 5-HT2A receptors at both spinal and central levels, as well as neuroplastic actions that improve functional connectivity in brain regions involved in chronic pain, are considered. Current clinical aspects and the translational potential of psilocybin from animal models to chronic pain patients are reviewed. Also discussed is psilocybin's profile as an ideal anti- nociceptive agent, with a wide range of effects against chronic pain and its associated inflammatory or emotional components.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/119731
Identification Number/DOI	10.1111/bph.17420
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	Wiley
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