Development of squamous cell carcinoma at the bite sites several years following suspected cobra (Naja naja) envenomings

Senthilkumaran, S., Almeida, J. R., Williams, J., Williams, H., Thirumalaikolundusubramanian, P. and Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517 (2024) Development of squamous cell carcinoma at the bite sites several years following suspected cobra (Naja naja) envenomings. Clinical Toxicology. ISSN 1556-9519 doi: 10.1080/15563650.2024.2432407

Abstract/Summary

Introduction: Snakebite envenoming is a multidimensional issue that causes severe functional and life-challenging consequences among rural communities in tropical countries. Current research and treatments are largely focused on acute envenomation effects and short-term health outcomes. The knowledge of snakebite-induced long-term consequences is highly limited. Case reports: We report the development of squamous cell carcinoma at the bite site several years later in four patients who are suspected to have been bitten by cobras (Naja naja). Following bites, the victims presented typical symptoms of cobra envenomings including ptosis, altered sensorium and breathing difficulties. However, a difficult-to-heal wound remained a chronic health sequela with frequent desquamation cycles which led to squamous cell carcinoma. Surgery as the primary therapeutic approach was used for all patients to tackle this issue. Discussion: These cases highlight the significance of squamous cell carcinoma in previously damaged tissue by snakebites as a possible long-term consequence. This emphasises the need for surveillance systems focused on a broad range of snakebite-induced consequences including long-term pathological, psychological, and socioeconomic conditions. Conclusion: This case collection describes an intriguing pathological complication following cobra bites that requires further research to determine mechanistic and epidemiological insights in the most affected regions by snakebites, specifically India.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/119444
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	Taylor and Francis
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