Microstructural white matter changes underlying speech deficits in Parkinson’s disease

Mollaei, F. ORCID: https://orcid.org/0000-0003-2916-9750 and Basha Chinoor, M. A. (2024) Microstructural white matter changes underlying speech deficits in Parkinson’s disease. Brain and Language, 249. 105378. ISSN 0093-934x doi: 10.1016/j.bandl.2024.105378

Abstract/Summary

Speech impairments are one of the common symptoms of individuals with Parkinson’s disease (PD). However, little is known about the underlying neuroanatomical structural deficits specifically in the basal gangliathalamocortical (BGTC) loop in the speech deficits of PD. Here we investigated white matter differences in PD using probabilistic tractography. Diffusion tensor imaging data were downloaded from the Parkinson’s Progression Markers Initiative database. We included three groups of participants: 20 PD individuals with speech deficits, 20 PD individuals without speech deficits, and 20 age- and gender matched control participants. Overall, PD individuals with speech deficits had higher mean diffusivity in the BGTC pathway in the left hemisphere compared with PD individuals without speech deficits. The present study exhibits that there may be a distinct pathophysiological profile of white matter for speech deficits in PD.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/114650
Identification Number/DOI	10.1016/j.bandl.2024.105378
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Life Sciences > School of Psychology and Clinical Language Sciences > Department of Clinical Language Sciences
Publisher	Elsevier
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