Asymmetric synthesis of arylalanines via asymmetric aza-darzens (ADZ) reaction

Maguire, N.E., McLaren, A.B. and Sweeney, J.B. (2003) Asymmetric synthesis of arylalanines via asymmetric aza-darzens (ADZ) reaction. Synlett, 12. pp. 1898-1900. ISSN 0936-5214 doi: 10.1055/s-2003-41470

Abstract/Summary

(R)-3-Arylalanines may be prepared in high enantiomeric purity from N-dpp imines by a four-step reaction sequence involving asymmetric aza-Darzens reaction, dephosphinylation, hydrogenolysis and hydrolysis. The amino acids thus obtained were of >95% enantiomeric purity.