Discovery of a human monoclonal antibody that cross-neutralizes venom phospholipase A2s from three different snake genera

Sørensen, C. V., Almeida, J. R. ORCID: https://orcid.org/0000-0002-4637-4468, Bohn, M.-F., Torre, E. R. d., Schoffelen, S., Voldborg, B. G., Ljungars, A., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517 and Laustsen, A. H. (2023) Discovery of a human monoclonal antibody that cross-neutralizes venom phospholipase A2s from three different snake genera. Toxicon, 234. 107307. ISSN 0041-0101 doi: 10.1016/j.toxicon.2023.107307

Abstract/Summary

Despite the considerable global impact of snakebite envenoming, available treatments remain suboptimal. Here, we report the discovery of a broadly-neutralizing human monoclonal antibody, using a phage display-based cross-panning strategy, capable of reducing the cytotoxic effects (using a mouse myoblast cell line that may demonstrate the impact of venoms on skeletal muscle) of venom phospholipase A2s from three different snake genera from different continents. This highlights the potential of utilizing monoclonal antibodies to potentially compose more effective, safer, and globally accessible polyvalent antivenoms that hopefully can be widely applicable for snakebite envenomings.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/113507
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	Elsevier
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