Determining the metabolic fate of human milk oligosaccharides: it may just be more complex than you think?

Jackson, P. P. J., Wijeyesekera, A. ORCID: https://orcid.org/0000-0001-6151-5065 and Rastall, R. A. (2022) Determining the metabolic fate of human milk oligosaccharides: it may just be more complex than you think? Gut Microbiome, 3. e9. ISSN 2632-2897 doi: 10.1017/gmb.2022.8

Abstract/Summary

Human milk oligosaccharides (HMOs) are a class of structurally diverse and complex unconjugated glycans present in breast milk, which act as selective substrates for several genera of select microbes and inhibit the colonisation of pathogenic bacteria. Yet, not all infants are breastfed, instead being fed with formula milks which may or may not contain HMOs. Currently, formula milks only possess two HMOs: 2′-fucosyllactose (2’FL) and lacto-N-neotetraose (LNnT), which have been suggested to be similarly effective as human breast milk in supporting age-related growth. However, the in vivo evidence regarding their ability to beneficially reduce respiratory infections along with altering the composition of an infant’s microbiota is limited at best. Thus, this review will explore the concept of HMOs and their metabolic fate, and summarise previous in vitro and in vivo clinical data regarding HMOs, with specific regard to 2’FL and LNnT.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/111921
Identification Number/DOI	10.1017/gmb.2022.8
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Microbial Sciences Research Group Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Food Research Group
Publisher	Cambridge University Press
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