Stepwise self-assembly of a tripeptide from molecular dimers to supramolecular beta-sheets in crystals and amyloid-like fibrils in the solid state

Das, A.K., Banerjee, A., Drew, M.G.B., Haldar, D. and Banerjee, A. (2004) Stepwise self-assembly of a tripeptide from molecular dimers to supramolecular beta-sheets in crystals and amyloid-like fibrils in the solid state. Supramolecular Chemistry, 16 (5). pp. 331-335. ISSN 1061-0278 doi: 10.1080/1061027042000213047

Abstract/Summary

The terminally protected tripeptide Boc-Ala(1)-Leu(2)-Ala(3)-OMe 1 forms antiparallel hydrogen-bonded dimers of two different conformers in the asymmetric unit and the individual dimers then self-associate to form supramolecular beta-sheet structures in crystals and amyloid-like fibrils in the solid state.