Biodegradable hydrogels based on chitosan and pectin for cisplatin delivery

Vildanova, R. R., Petrova, S. F., Kolesov, S. V. and Khutoryanskiy, V. ORCID: https://orcid.org/0000-0002-7221-2630 (2023) Biodegradable hydrogels based on chitosan and pectin for cisplatin delivery. Gels, 9 (4). 342. ISSN 2310-2861 doi: 10.3390/gels9040342

Abstract/Summary

Preparation of stable hydrogels using physically (electrostatically) interacting charge-complementary polyelectrolyte chains seems to be more attractive from a practical point of view than the use of organic crosslinking agents. In this work natural polyelectrolytes—chitosan and pectin—were used, due to their biocompatibility and biodegradability. The biodegradability of hydrogels is confirmed by experiments with hyaluronidase as an enzyme. It has been shown that the use of pectins with different molecular weights makes it possible to prepare hydrogels with different rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels loaded with cytostatic cisplatin as a model drug provide an opportunity for its prolonged release, which is important for therapy. The drug release is regulated to a certain extent by the choice of hydrogel composition. The developed systems can potentially improve the effects of cancer treatment due to the prolonged release of cytostatic cisplatin.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/111635
Identification Number/DOI	10.3390/gels9040342
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	MDPI
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