Development and psychometric validation of a patient-reported outcome measure of recurrent urinary tract infection impact: the Recurrent UTI Impact Questionnaire

Newlands, A. F. ORCID: https://orcid.org/0000-0002-4718-0075, Roberts, L. ORCID: https://orcid.org/0000-0001-5277-2377, Maxwell, K. ORCID: https://orcid.org/0000-0002-8747-7201, Kramer, M. ORCID: https://orcid.org/0000-0002-9242-5203, Price, J. L. ORCID: https://orcid.org/0000-0002-0487-0826 and Finlay, K. A. ORCID: https://orcid.org/0000-0002-8997-2652 (2023) Development and psychometric validation of a patient-reported outcome measure of recurrent urinary tract infection impact: the Recurrent UTI Impact Questionnaire. Quality of Life Research, 32. pp. 1745-1758. ISSN 1573-2649 doi: 10.1007/s11136-023-03348-7

Abstract/Summary

Recurrent urinary tract infection (rUTI) is a highly prevalent condition associated with significant poor quality of life outcomes. A patient-reported outcome measure (PROM) of rUTI-associated psychosocial impact is urgently required to supplement clinical evaluation and validate the challenges experienced by patients. This study therefore developed and validated the Recurrent UTI Impact Questionnaire (RUTIIQ). A rigorous four-stage methodology was followed: (I) concept elicitation through a qualitative survey of the experiences of people with rUTI (N = 1983); (II) Delphi expert screening of the RUTIIQ with expert rUTI clinicians (N = 15); (III) one-to-one cognitive interviews with people experiencing rUTI (N = 28) to evaluate the comprehensiveness and comprehensibility of the RUTIIQ, and (IV) full pilot testing of the RUTIIQ with people experiencing rUTI (N = 240) to perform final item reduction and psychometric analysis. Exploratory factor analysis demonstrated a five-factor structure comprising: 'patient satisfaction', 'work and activity interference', 'social wellbeing', 'personal wellbeing', and 'sexual wellbeing', collectively accounting for 73.8% of the total variance in pilot scores. Results from expert clinicians and patients indicated strong item content validity (I-CVI > .75). The internal consistency and test-retest reliability of the RUTIIQ subscales were excellent (Cronbach's α = .81-.96, ICC = .66-.91), and construct validity was strong (Spearman's ρ > .69). The RUTIIQ is a 30-item questionnaire with excellent psychometric properties, assessing the patient-reported psychosocial impact of living with rUTI symptoms and pain. This new instrument delivers the unique opportunity to enhance patient-centred care through standardised observation and monitoring of rUTI patient outcomes. This study was pre-registered with ClinicalTrials.gov (identifier: NCT05086900). [Abstract copyright: © 2023. The Author(s).]

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/110726
Identification Number/DOI	10.1007/s11136-023-03348-7
Refereed	Yes
Divisions	Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology
Uncontrolled Keywords	Patient-reported outcomes, Recurrent urinary tract infection, Women’s health, Chronic pain, Urinary tract infection, Patient-centred care
Publisher	Springer
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