Ligand bridging of the DNA Holliday junction: molecular recognition of a stacked-X four-way junction by a small molecule

Brogden, A.L., Hopcroft, N.H., Searcey, M. and Cardin, C.J. ORCID: https://orcid.org/0000-0002-2556-9995 (2007) Ligand bridging of the DNA Holliday junction: molecular recognition of a stacked-X four-way junction by a small molecule. Angewandte Chemie-International Edition, 46 (21). pp. 3850-3854. ISSN 1433-7851 doi: 10.1002/anie.200603760

Abstract/Summary

Planning a Holliday: A new mode of binding to a stacked-X, four-way Holliday junction is described in which a chromophore molecule binds across the center of the junction and two adenine residues are replaced by the acridine chromophores at either side of the crossover. This binding mode is specific for the Holliday junction and does not cause unwinding of the DNA helices.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/11053
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Uncontrolled Keywords	bridging ligands, DNA structures, ligand design, structure elucidation, X-ray diffraction, CRYSTAL-STRUCTURE, G-QUADRUPLEX, BINDING, CELLS, RECOMBINATION, SEQUENCE, POISON
Download/View statistics	View download statistics for this item