Micelle and nanotape formation of Benzene Tricarboxamide analogues with selective cancer cell cytotoxicity

Aljuaid, N., Seitsonen, J., Ruokolainen, J., Greco, F. ORCID: https://orcid.org/0000-0001-7934-0056 and Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926 (2022) Micelle and nanotape formation of Benzene Tricarboxamide analogues with selective cancer cell cytotoxicity. ACS Omega, 7 (50). pp. 46843-46848. ISSN 2470-1343 doi: 10.1021/acsomega.2c05940

Abstract/Summary

Analogues of benzene-1,3,5-tricarboxamide bearing combinations of different alkyl chains (dodecyl to octadecyl) and ester-linked PEG (polyethylene glycol) chains are shown to self-assemble into either micelles or nanotapes in aqueous solution, depending on the architecture (number of alkyl vs PEG chains). The cytotoxicity to cells is selectively greater for breast cancer cells than fibroblast controls in a dose-dependent manner. The compounds show strong stability, retaining their self-assembled structures at low pH (relevant to acidic tumor conditions) and in buffer and cell culture media.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/109273
Identification Number/DOI	10.1021/acsomega.2c05940
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	ACS Publications
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