Antifungal nanosuspensions with surfactants and silver for the treatment of onychomycosis

Al-Obaidi, H. ORCID: https://orcid.org/0000-0001-9735-0303, Petraityte, I., Hibbard, T., Majumder, M., Kalgudi, R. and Zariwala, M. G. (2022) Antifungal nanosuspensions with surfactants and silver for the treatment of onychomycosis. European Journal of Pharmaceutics and Biopharmaceutics, 179. pp. 194-205. ISSN 0939-6411 doi: 10.1016/j.ejpb.2022.09.004

Abstract/Summary

Fungal nail infection (Onychomycosis) often requires prolonged treatment and is associated with a high risk of resistance to treatment. Here in this contribution, we introduce a novel approach to enhance penetration and antifungal activity of the antifungal drug griseofulvin (GF). Solid dispersions were prepared with hydroxypropyl methylcellulose acetate succinate (HPMCAS) and combined with surfactant (either sodium dodecyl sulphate (SDS), dodecyl trimethylammonium bromide (DTAB), or Pluronic F127) using mechanochemical activation. The prepared powders were then suspended with spray-dried silica-coated silver nanoparticles and applied onto infected bovine hooves to assess permeability and antifungal activity. The results showed that the prepared nanosuspensions significantly suppressed fungal activity causing disruption of fungal biofilms. Raman mapping showed enhanced permeation while dynamic vapor sorption (DVS), and particle size measurements showed varied effects depending on the type of surfactant and milling conditions. The prepared nanosuspensions dis- played enhanced solubility of the poorly soluble drug reaching approximately 1.2 mg/mL. The results showed that the dispersions that contained DTAB displayed maximum efficacy while the inclusion of colloidal silver did not seem to significantly improve the antifungal activity compared to other formulations.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/107541
Identification Number/DOI	10.1016/j.ejpb.2022.09.004
Refereed	No
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Optical Spectroscopy (CAF) Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Thermal Analysis (CAF) Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Xray (CAF) Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Electron Microscopy Laboratory (CAF)
Publisher	Elsevier
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