Resting-state functional connectivity does not predict individual differences in the effects of emotion on memory

Kandaleft, D., Murayama, K., Roesch, E. ORCID: https://orcid.org/0000-0002-8913-4173 and Sakaki, M. ORCID: https://orcid.org/0000-0003-1993-5765 (2022) Resting-state functional connectivity does not predict individual differences in the effects of emotion on memory. Scientific Reports, 12. 14481. ISSN 2045-2322 doi: 10.1038/s41598-022-18543-8

Abstract/Summary

Emotion-laden events and objects are typically better remembered than neutral ones. This is usually explained by stronger functional coupling in the brain evoked by emotional content. However, most research on this issue has focused on functional connectivity evoked during or after learning. The effect of an individual’s functional connectivity at rest is unknown. Our pre-registered study addresses this issue by analysing a large database, the Cambridge Centre for Ageing and Neuroscience, which includes resting-state data and emotional memory scores from 303 participants aged 18–87 years. We applied regularised regression to select the relevant connections and replicated previous findings that whole-brain resting-state functional connectivity can predict age and intelligence in younger adults. However, whole-brain functional connectivity predicted neither an emotional enhancement effect (i.e., the degree to which emotionally positive or negative events are remembered better than neutral events) nor a positivity bias effect (i.e., the degree to which emotionally positive events are remembered better than negative events), failing to support our pre-registered hypotheses. These results imply a small or no association between individual differences in functional connectivity at rest and emotional memory, and support recent notions that resting-state functional connectivity is not always useful in predicting individual differences in behavioural measures.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/106900
Item Type	Article
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology Life Sciences > School of Psychology and Clinical Language Sciences > Neuroscience
Publisher	Nature Publishing Group
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