Polyaphron formulations stabilised with different water-soluble polymers for ocular drug delivery

Moiseev, R. V. ORCID: https://orcid.org/0000-0002-4358-9981, Steele, F. and Khutoryanskiy, V. V. ORCID: https://orcid.org/0000-0002-7221-2630 (2022) Polyaphron formulations stabilised with different water-soluble polymers for ocular drug delivery. Pharmaceutics, 14 (5). pp. 1-20. ISSN 1999-4923 doi: 10.3390/pharmaceutics14050926

Abstract/Summary

As drug delivery to the eye has evolved over the last decades, researchers have explored more effective treatments for ocular diseases. Despite this, delivering drugs to the cornea remains one of the most problematic issues in ophthalmology due to the poor permeability of the cornea and tear clearance mechanisms. In this study, four different types of polyaphron formulations are prepared with 10% poloxamer 188 (P188), 10% poly(2-ethyl-2-oxazoline), 1% polyquaternium 10, and 3% sodium carboxymethylcellulose solutions mixed with 1% Brij® L4 in a caprylic/capric triglycerides solution. Their physicochemical characteristics, rheological properties, and stability are assessed. Additionally, a polyaphron with 3% polyquaternium 10 was prepared for the assessment of ex vivo corneal retention along with four other polyaphrons. The best retention on the ex vivo cornea was displayed by the 3% polyquaternium 10-based formulation. The 10% poloxamer 188 along with 1% polyquaternium 10-based polyaphrons appeared to be the most stable among the four prepared formulations. A toxicological evaluation of these formulations was performed using a slug mucosal irritation test and bovine corneal opacity and permeability assay, with all four polyaphrons proving good biocompatibility with ocular tissues. The developed drug delivery systems demonstrated an excellent potential for ocular drug delivery.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/104969
Identification Number/DOI	10.3390/pharmaceutics14050926
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	MDPI
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