Peptides for vaccine development

Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926 (2022) Peptides for vaccine development. ACS Applied Bio Materials, 5 (3). pp. 905-944. ISSN 2576-6422 doi: 10.1021/acsabm.1c01238

Abstract/Summary

This review discusses peptide epitopes used as antigens in the development of vaccines in clinical trials as well as future vaccine candidates. It covers peptides used in potential immunotherapies for infectious diseases including SARS-CoV-2, influenza, hepatitis B and C, HIV, malaria, and others. In addition, peptides for cancer vaccines that target examples of overexpressed proteins are summarized, including human epidermal growth factor receptor 2 (HER-2), mucin 1 (MUC1), folate receptor, and others. The uses of peptides to target cancers caused by infective agents, for example, cervical cancer caused by human papilloma virus (HPV), are also discussed. This review also provides an overview of model peptide epitopes used to stimulate non-specific immune responses, and of self-adjuvanting peptides, as well as the influence of other adjuvants on peptide formulations. As highlighted in this review, several peptide immunotherapies are in advanced clinical trials as vaccines, and there is great potential for future therapies due the specificity of the response that can be achieved using peptide epitopes.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/103824
Identification Number/DOI	10.1021/acsabm.1c01238
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Publisher	American Chemical Society (ACS)
Download/View statistics	View download statistics for this item