Role of gamma-MSH peptides in the regulation of adrenal steroidogenesis

Harmer, S. C. and Bicknell, A. B. (2005) Role of gamma-MSH peptides in the regulation of adrenal steroidogenesis. Peptides, 26 (10). pp. 1944-1951. ISSN 0196-9781 doi: 10.1016/j.peptides.2004.11.028

Abstract/Summary

Alpha-, beta- and gamma-melanocyte stimulating hormones (MSHs) are peptides derived from the ACTH precursor, pro-opiomelanocortin. All three peptides have been highly conserved throughout evolution but their exact biological function in mammals is still largely obscure. In recent years, there has been a surge of interest in alpha-MSH and its role in the regulation of feeding. Gamma-MSH by contrast has been shown to be involved in the regulation of adrenal steroidogenesis and also has effects on the cardiovascular and renal systems. This review will provide an overview of the role that gamma-MSH peptides play in the regulation of adrenal steroidogenesis. (c) 2005 Elsevier Inc. All rights reserved.