Interaction between dietary fat intake and metabolic genetic risk score on 25-hydroxyvitamin D concentrations in a Turkish adult population

Isgin Atici, K., Alathari, B. E., Turan-Dermici, B., Sendur, S. N., Lay, I., Ellahi, B., Alikasifoglu, M., Erbas, T., Buyuktuncer, Z. and Vimaleswaran, K. S. ORCID: https://orcid.org/0000-0002-8485-8930 (2022) Interaction between dietary fat intake and metabolic genetic risk score on 25-hydroxyvitamin D concentrations in a Turkish adult population. Nutrients, 14 (2). ISSN 2072-6643 doi: 10.3390/nu14020382

Abstract/Summary

Previous studies have pointed out a link between vitamin D status and metabolic traits, however, consistent evidence has not been provided yet. This cross-sectional study has used a nutrigenetic approach to investigate the interaction between metabolic-genetic risk score (GRS) and dietary intake on serum 25-hydroxyvitamin D [25(OH)D] concentrations in 396 unrelated Turkish adults, aged 24–50 years. Serum 25(OH)D concentration was significantly lower in those with a metabolic-GRS ≥ 1 risk allele than those with a metabolic-GRS < 1 risk allele (p = 0.020). A significant interaction between metabolic-GRS and dietary fat intake (energy%) on serum 25(OH)D levels was identified (Pinteraction = 0.040). Participants carrying a metabolic-GRS ≥ 1 risk allele and consuming a high fat diet (≥38% of energy = 122.3 ± 52.51 g/day) had significantly lower serum 25(OH)D concentration (p = 0.006) in comparison to those consuming a low-fat diet (<38% of energy = 82.5 ± 37.36 g/d). In conclusion, our study suggests a novel interaction between metabolic-GRS and dietary fat intake on serum 25(OH)D level, which emphasises that following the current dietary fat intake recommendation (<35% total fat) could be important in reducing the prevalence of vitamin D deficiency in this Turkish population. Nevertheless, further larger studies are needed to verify this interaction, before implementing personalized dietary recommendations for the maintenance of optimal vitamin D status.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/102387
Identification Number/DOI	10.3390/nu14020382
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Institute for Food, Nutrition and Health (IFNH) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Publisher	MDPI
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