Genome-nanosurface interaction of Titania Nanotube Arrays: evaluation of telomere, telomerase and NF-κB activities on epithelial cell model

Mydin, R. S. M. N., Sreekantan, S., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X, Saharudin, K. A., Hazan, R. and Wajidi, M. F. F. (2022) Genome-nanosurface interaction of Titania Nanotube Arrays: evaluation of telomere, telomerase and NF-κB activities on epithelial cell model. RSC Advances, 12 (4). pp. 2237-2245. ISSN 2046-2069 doi: 10.1039/D1RA05325F

Abstract/Summary

Titanium Dioxide Nanotube Arrays (TNA) provides promising platform for medical implants and nanomedicine applications. The present cell-TNA study has provided profound understanding on protection of genome integrity via telomere, telomerase and NF-κB activities using epithelial cell model. It has been revealed in this study that cell-TNA interaction triggers the telomere shortening activity and inhibition of telomerase activity at mRNA and protein level. The present work supported that cell-TNA stimulus might involve controlled transcription and proliferative activities via NBN and TERF21P mechanisms. Moreover, inhibition of NF-κB may promote molecular sensitivity via senescence -associated secretory phenotype activities and might results in reduced inflammatory response which would be good for cell and nanosurface adaptation activities. Thus, this nanomaterial-molecular knowledge is beneficial for further nanomaterial characterization and advanced medical application.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/101980
Identification Number/DOI	10.1039/D1RA05325F
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	Royal Society of Chemistry
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