Stabilization of long-looped i-motif DNA by polypyridyl ruthenium complexes

Pages, B. J., Gurung, S. P., McQuaid, K. ORCID: https://orcid.org/0000-0002-3222-5584, Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 and Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X (2019) Stabilization of long-looped i-motif DNA by polypyridyl ruthenium complexes. Frontiers in Chemistry, 7. 744. ISSN 2296-2646 doi: 10.3389/fchem.2019.00744

Abstract/Summary

A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen)2(dppz)]2+ with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the Λ enantiomer was enhanced much more than the Δ. Despite this, the effect of each enantiomer on i-motif thermal stability was comparable. The sequences most affected by [Ru(phen)2(dppz)]2+ were those with long thymine loops; this suggests that long-looped i-motifs are attractive targets for potential transition metal complex drugs and should be explored further in drug design.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/87365
Identification Number/DOI	10.3389/fchem.2019.00744
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Uncontrolled Keywords	Chemistry, i-motif, DNA, ruthenium, melting, stabilization, luminescence
Publisher	Frontiers Media S.A.
Download/View statistics	View download statistics for this item