X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes

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McQuaid, K., Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Cardin, D. J. and Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 (2018) X-ray crystal structures show DNA stacking advantage of terminal nitrile substitution in Ru-dppz complexes. Chemistry- A European Journal, 24 (59). pp. 15859-15867. ISSN 1521-3765 doi: 10.1002/chem.201803021

Abstract/Summary

The new complexes [Ru(TAP)2(11-CN-dppz)]2+, [Ru(TAP)2(11-Br-dppz)]2+and [Ru(TAP)2(11,12-diCN-dppz)]2+ are reported. The addition of nitrile substituents to the dppz ligand of the DNA photooxidising complex [Ru(TAP)2(dppz)]2+ promote π-stacking interactions and ordered binding to DNA, as shown by X-ray crystallography. The structure of -[Ru(TAP)2(11-CN-dppz)]2+ with the DNA duplex d(TCGGCGCCGA)2 shows, for the first time with this class of complex, a closed intercalation cavity with an AT base pair at the terminus. The structure obtained is compared to that formed with the 11-Br and 11,12-dinitrile derivatives, highlighting the stabilization of syn guanine by this enantiomer when the terminal basepair is GC. In contrast the AT basepair has the normal Watson-Crick orientation, highlighting the difference in charge distribution between the two purine bases and the complementarity of the dppz-purine interaction. The asymmetry of the cavity highlights the importance of the purine-dppz-purine stacking interaction.

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Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/78413
Identification Number/DOI	10.1002/chem.201803021
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > NMR (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Division of Pharmacology
Publisher	Wiley
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Funders:	Biotechnology and Biological Sciences Research Council	The sponsoring bodies who contributed funding for the creation of this item. Example: NERC Example: The Royal Society of Chemistry A pick list of funders may appear as you type in the funder's name in full or as an acronym. Select a correct match to complete the field or type in a new entry in full. For new entries, the full name is preferred.
Projects:	Metal polypyridyl complex interactions with duplex and higher order DNAs Funded by: Biotechnology and Biological Sciences Research Council (BB/K019279/1 - £441,977) Local Lead (PI): Christine Cardin Project Lead: Christine Janet Cardin 1 October 2013 - 30 September 2016 ETNA - Expansion of the Time domain in Nucleic Acid crystallography Funded by: Biotechnology and Biological Sciences Research Council (BB/M004635/1 - £368,984) Project Lead: Christine Janet Cardin 1 October 2014 - 30 September 2017	Click Add to select your project (received at Reading) from an autocomplete list.

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Date Deposited:	09 Aug 2018 15:21	Date item deposited into CentAUR
Last Modified:	04 Dec 2024 02:34	Date item last modified

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