Parshotam, J. P., Brazier, J. A. ORCID: https://orcid.org/0000-0002-4952-584X, Bovill, R. and Osborn, H. M. I.
ORCID: https://orcid.org/0000-0002-0683-0457
(2016)
An efficient and rapid microwave-assisted synthesis of 1-acetyl-1H-indol-3-YL acetates.
Current Microwave Chemistry, 3 (3).
pp. 247-257.
ISSN 2213-3364
doi: 10.2174/2213335603666160108001556
Abstract/Summary
An efficient and rapid synthesis of 1-acetyl-1H-indol-3-yl acetate 1 and its derivatives 7 via the microwave-assisted cyclisation and decarboxylation of 2-[(carboxymethyl)amino]benzoic acids 5 is described. The latter were left to react with acetic anhydride using triethylamine as the base and were subjected to microwave irradiation for 1 minute, at 80 °C with initial power of 300 W. The target 1-acetyl-1H-indol-3-yl acetate 1 and derivatives 7 were isolated in 34-71% yield. In particular, synthesis of 1-acetyl-6-(trifluoromethyl)-1H-indol-3-yl acetate 7f and 1-acetyl-3-methyl-1H-indol-3-yl acetate 7h is reported for the first time.
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Item Type | Article |
URI | https://reading-clone.eprints-hosting.org/id/eprint/51462 |
Item Type | Article |
Refereed | Yes |
Divisions | Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group |
Uncontrolled Keywords | microwave; synthesis; cyclisation; indoxyls; indoles |
Publisher | Bentham |
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