Neuromotor tolerability and behavioural characterisation of cannabidiolic acid, a phytocannabinoid with therapeutic potential for anticipatory nausea

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Ahlberg K, Ekman T, Gaston-Johansson F, Mock V (2003) Assessment and management of cancer-related fatigue in adults. Lancet 362:640–50. doi: 10.1016/S0140-6736(03)14186-4 Basch E, Prestrud AA, Hesketh PJ, et al (2012) Antiemetic Use in Oncology: Updated Guideline Recommendations from ASCO. Am Soc Clin Oncol Educ Book 532–40. doi: 10.14694/EdBook_AM.2012.32.532 Bolognini D, Rock EM, Cluny NL, et al (2013) Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. Br J Pharmacol 168:1456–70. doi: 10.1111/bph.12043 Bourin M, Hascoët M (2003) The mouse light/dark box test. Eur J Pharmacol 463:55–65. doi: 10.1016/S0014-2999(03)01274-3 Bovbjerg DH (2006) The continuing problem of post chemotherapy nausea and vomiting: contributions of classical conditioning. Auton Neurosci 129:92–8. doi: 10.1016/j.autneu.2006.07.016 Britton DR, Britton KT (1981) A sensitive open field measure of anxiolytic drug activity. Pharmacol Biochem Behav 15:577–82. doi: 10.1016/0091-3057(81)90212-4 Campos AC, Moreira FA, Gomes F V., et al (2012) Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc B Biol Sci 367:3364–3378. doi: 10.1098/rstb.2011.0389 Campos D, Pereira JR, Reinhardt RR, et al (2001) Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist, MK-869, in combination with granisetron and dexamethasone or with dexamethasone alone. J Clin Oncol 19:1759–67. Cluny NL, Naylor RJ, Whittle BA, Javid FA (2011) The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus. Arch Pharm Res 34:1509–17. doi: 10.1007/s12272-011-0913-6 Curzon P, Zhang M, Radek R, Fox G (2009) The Behavioral Assessment of Sensorimotor Processes in the Mouse: Acoustic Startle, Sensory Gating, Locomotor Activity, Rotarod, and Beam Walking. Methods Behav. Anal. Neurosci. Dos Santos LV, Souza FH, Brunetto AT, et al (2012) Neurokinin-1 receptor antagonists for chemotherapy-induced nausea and vomiting: a systematic review. J Natl Cancer Inst 104:1280–92. doi: 10.1093/jnci/djs335 Dulawa SC, Hen R (2005) Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test. Neurosci Biobehav Rev 29:771–83. doi: 10.1016/j.neubiorev.2005.03.017 Duvvuri V, Risbrough VB, Kaye WH, Geyer MA (2009) 5-HT1A receptor activation is necessary for 5-MeODMT-dependent potentiation of feeding inhibition. Pharmacol Biochem Behav 93:349–53. doi: 10.1016/j.pbb.2009.05.014 Farrimond JA, Hill AJ, Whalley BJ, Williams CM (2010a) Cannabis constituents modulate δ9-tetrahydrocannabinol-induced hyperphagia in rats. Psychopharmacology (Berl) 210:97–106. doi: 10.1007/s00213-010-1821-z Farrimond JA, Whalley BJ, Williams CM (2012a) Non-Δ9tetrahydrocannabinol phytocannabinoids stimulate feeding in rats. Behav Pharmacol 23:113–7. doi: 10.1097/FBP.0b013e32834ed832 Farrimond JA, Whalley BJ, Williams CM (2012b) Cannabinol and cannabidiol exert opposing effects on rat feeding patterns. Psychopharmacology (Berl) 223:117–29. doi: 10.1007/s00213-012-2697-x Farrimond JA, Whalley BJ, Williams CM (2010b) A low-Δ9tetrahydrocannabinol cannabis extract induces hyperphagia in rats. Behav Pharmacol. doi: 10.1097/FBP.0b013e328340a062 Ferguson SA, Paule MG (1996) Effects of chlorpromazine and diazepam on time estimation behavior and motivation in rats. Pharmacol Biochem Behav 53:115–22. doi: 10.1016/0091-3057(95)02002-0 Figueroa-Moseley C, Jean-Pierre P, Roscoe JA, et al (2007) Behavioral interventions in treating anticipatory nausea and vomiting. J Natl Compr Canc Netw 5:44–50. Griebel G, Rodgers RJ, Perrault G, Sanger DJ (1999) Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT 1A receptor antagonists. Psychopharmacology (Berl) 144:121–130. doi: 10.1007/s002130050984 Griebel G, Rodgers RJ, Perrault G, Sanger DJ (2000) The effects of compounds varying in selectivity as 5-HT1A receptor antagonists in three rat models of anxiety. Neuropharmacology 39:1848–1857. doi: 10.1016/S0028-3908(00)00074-5 Gross C, Santarelli L, Brunner D, et al (2000) Altered fear circuits in 5-HT(1A) receptor KO mice. Biol Psychiatry 48:1157–63. doi: 10.1016/S0006-3223(00)01041-6 Hainsworth JD, Hesketh PJ (1992) Single-dose ondansetron for the prevention of cisplatin-induced emesis: efficacy results. Semin Oncol 19:14–9. Hesketh PJ (2008) Chemotherapy-induced nausea and vomiting. N Engl J Med 358:2482–94. doi: 10.1056/NEJMra0706547 Hesketh PJ, Grunberg SM, Gralla RJ, et al (2003) The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin--the Aprepitant Protocol 052 Study Gr. J Clin Oncol 21:4112–9. doi: 10.1200/JCO.2003.01.095 Hickok JT, Roscoe JA, Morrow GR, et al (2003) Nausea and emesis remain significant problems of chemotherapy despite prophylaxis with 5-hydroxytryptamine-3 antiemetics: a University of Rochester James P. Wilmot Cancer Center Community Clinical Oncology Program Study of 360 cancer patients treated in t. Cancer 97:2880–6. doi: 10.1002/cncr.11408 Hill AJ, Mercier MS, Hill TDM, et al (2012) Cannabidivarin is anticonvulsant in mouse and rat. Br J Pharmacol 167:1629–42. doi: 10.1111/j.1476-5381.2012.02207.x Hill TDM, Cascio M-G, Romano B, et al (2013) Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism. Br J Pharmacol 170:679–92. doi: 10.1111/bph.12321 Janelsins MC, Tejani MA, Kamen C, et al (2013) Current pharmacotherapy for chemotherapy-induced nausea and vomiting in cancer patients. Expert Opin Pharmacother 14:757–66. doi: 10.1517/14656566.2013.776541 Kamen C, Tejani MA, Chandwani K, et al (2014) Anticipatory nausea and vomiting due to chemotherapy. Eur J Pharmacol 722:172–9. doi: 10.1016/j.ejphar.2013.09.071 Kilkenny C, Browne W, Cuthill IC, et al (2010) Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160:1577–9. doi: 10.1111/j.1476-5381.2010.00872.x Kris MG, Hesketh PJ, Somerfield MR, et al (2006) American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006. J Clin Oncol 24:2932–47. doi: 10.1200/JCO.2006.06.9591 Lotfi-Jam K, Carey M, Jefford M, et al (2008) Nonpharmacologic strategies for managing common chemotherapy adverse effects: a systematic review. J Clin Oncol 26:5618–29. doi: 10.1200/JCO.2007.15.9053 Malik IA, Khan WA, Qazilbash M, et al (1995) Clinical efficacy of lorazepam in prophylaxis of anticipatory, acute, and delayed nausea and vomiting induced by high doses of cisplatin. A prospective randomized trial. Am J Clin Oncol 18:170–5. Martin M (1996) The severity and pattern of emesis following different cytotoxic agents. Oncology 53 Suppl 1:26–31. doi: 10.1159/000227637 Matteson S, Roscoe J, Hickok J, Morrow GR (2002) The role of behavioral conditioning in the development of nausea. Am J Obstet Gynecol 186:S239–43. doi: 10.1067/mob.2002.122597 McGrath JC, Drummond GB, McLachlan EM, et al (2010) Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160:1573–6. doi: 10.1111/j.1476-5381.2010.00873.x Meyer OA, Tilson HA, Byrd WC, Riley MT (1979) A method for the routine assessment of fore- and hindlimb grip strength of rats and mice. Neurobehav Toxicol 1:233–6. Navari RM, Reinhardt RR, Gralla RJ, et al (1999) Reduction of cisplatin-induced emesis by a selective neurokinin-1-receptor antagonist. L-754,030 Antiemetic Trials Group. N Engl J Med 340:190–5. doi: 10.1056/NEJM199901213400304 Nesse RM, Carli T, Curtis GC, Kleinman PD (1980) Pretreatment nausea in cancer chemotherapy: a conditioned response? Psychosom Med 42:33–6. Prut L, Belzung C (2003) The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 463:3–33. doi: 10.1016/S0014-2999(03)01272-X Razavi D, Delvaux N, Farvacques C, et al (1993) Prevention of adjustment disorders and anticipatory nausea secondary to adjuvant chemotherapy: a double-blind, placebo-controlled study assessing the usefulness of alprazolam. J Clin Oncol 11:1384–90. Rex A, Voigt JP, Voits M, Fink H (1998) Pharmacological evaluation of a modified open-field test sensitive to anxiolytic drugs. Pharmacol Biochem Behav 59:677–83. doi: 10.1016/S0091-3057(97)00461-9 Rock E, Parker L (2013a) Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats. Br J Pharmacol. doi: 10.1111/bph.12162 Rock EM, Limebeer CL, Navaratnam R, et al (2014a) A comparison of cannabidiolic acid with other treatments for anticipatory nausea using a rat model of contextually elicited conditioned gaping. Psychopharmacology (Berl). doi: 10.1007/s00213-014-3498-1 Rock EM, Limebeer CL, Parker LA (2014b) Anticipatory nausea in animal models: a review of potential novel therapeutic treatments. Exp brain Res. doi: 10.1007/s00221-014-3942-9 Rock EM, Parker LA (2013b) Suppression of lithium chloride-induced conditioned gaping (a model of nausea-induced behaviour) in rats (using the taste reactivity test) with metoclopramide is enhanced by cannabidiolic acid. Pharmacol Biochem Behav 111:84–9. doi: 10.1016/j.pbb.2013.08.012 Roila F, Herrstedt J, Aapro M, et al (2010) Guideline update for MASCC and ESMO in the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting: results of the Perugia consensus conference. Ann Oncol 21 Suppl 5:v232–43. doi: 10.1093/annonc/mdq194 Roscoe JA, Morrow GR, Aapro MS, et al (2011) Anticipatory nausea and vomiting. Support Care Cancer 19:1533–8. doi: 10.1007/s00520-010-0980-0 Sánchez C (1996) 5-HT(1A) receptors play an important role in modulation of behavior of rats in a two-compartment black and white box. Behav Pharmacol 7:788–797. Schier AR de M, Ribeiro NP de O, Silva AC de O e, et al (2012) Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug. Rev Bras Psiquiatr 34 Suppl 1:S104–10. doi: 10.1590/S1516-44462012000500008 Stanley JL, Lincoln RJ, Brown TA, et al (2005) The mouse beam walking assay offers improved sensitivity over the mouse rotarod in determining motor coordination deficits induced by benzodiazepines. J Psychopharmacol 19:221–7. doi: 10.1177/0269881105051524 Stephens N, Fearon K (2008) Anorexia , cachexia and nutrition. Medicine (Baltimore) 36:78–81. doi: 10.1016/j.mpmed.2007.11.004 Williams CM, Kirkham TC (2002) Observational analysis of feeding induced by Delta9-THC and anandamide. Physiol Behav 76:241–50. doi: 10.1016/S0031-9384(02)00725-4 Williams CM, Rogers PJ, Kirkham TC (1998) Hyperphagia in pre-fed rats following oral delta9-THC. Physiol Behav 65:343–6. doi: 10.1016/S0031-9384(98)00170-X Zhang J, Huang X-Y, Ye M-L, et al (2010) Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors. J Neurosci 30:2433–41. doi: 10.1523/JNEUROSCI.5880-09.2010