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Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation

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Ura, S., Pollitt, A. Y. orcid id iconORCID: https://orcid.org/0000-0001-8706-5154, Veltman, D. M., Morrice, N. A., Machesky, L. M. and Insall, R. H. (2012) Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Current Biology, 22 (7). pp. 553-561. ISSN 0960-9822 doi: 10.1016/j.cub.2012.02.020

Abstract/Summary

Regulated dephosphorylation of a fraction of the cellular SCAR pool is a key step in SCAR activation during pseudopod growth. Phosphorylation increases autoinhibition of the intact complex. Dephosphorylation weakens this interaction and facilitates SCAR activation but also destabilizes the protein. We show that SCAR is specifically dephosphorylated in pseudopods, increasing activation by Rac and lipids and supporting positive feedback of pseudopod growth.

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Item Type Article
URI https://reading-clone.eprints-hosting.org/id/eprint/44793
Identification Number/DOI 10.1016/j.cub.2012.02.020
Refereed Yes
Divisions Life Sciences > School of Biological Sciences > Biomedical Sciences
Publisher Elsevier
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