The effects of whey proteins, their peptides and amino acids on vascular function

Price, D., Jackson, K. G. ORCID: https://orcid.org/0000-0002-0070-3203, Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455 and Givens, D. I. ORCID: https://orcid.org/0000-0002-6754-6935 (2022) The effects of whey proteins, their peptides and amino acids on vascular function. Nutrition Bulletin, 47 (1). pp. 9-26. ISSN 1467-3010 doi: 10.1111/nbu.12543

Abstract/Summary

Cardiovascular diseases (CVD) are a significant and growing burden on global health services, and it is now accepted that impairment of vascular function represents a major preliminary step in the development of CVD. There is considerable interest in identifying both causal factors of impaired vascular function, as well as related nutritional factors that may lower the risk of developing CVD, and food-derived bioactive peptides and amino acids have emerged as one such area. Dairy foods contain two groups of proteins, whey proteins and caseins, which represent a rich source of bioactive peptides that are released during food processing and/or digestion. These peptides have a number of physiological activities including the potential to reduce blood pressure. Research, including acute and longer-term randomised controlled trials, animal models and in vitro models has demonstrated the potential impact of dairy proteins on vascular function. The purpose of this paper is to narratively review the evidence, primarily from randomised controlled trials, examining the effects of whey proteins, their peptides and amino acids on vascular function and related issues including blood pressure. In addition, it will explore the potential underlying mechanisms responsible for these effects. It concludes that there is increasing evidence that whey proteins, and notably the bioactive peptides and amino acids released during their digestion, can have beneficial effects on aspects of vascular function and thus contribute to CVD risk reduction. It also highlights a number of beneficial effects of whey proteins including those

Additional Information	A Corrigendum to this article was published on 6 June 2022 and is available here: https://onlinelibrary.wiley.com/doi/10.1111/nbu.12564
Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/104346
Item Type	Article
Refereed	No
Divisions	Interdisciplinary Research Centres (IDRCs) > Institute for Food, Nutrition and Health (IFNH)
Additional Information	A Corrigendum to this article was published on 6 June 2022 and is available here: https://onlinelibrary.wiley.com/doi/10.1111/nbu.12564
Publisher	Wiley
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