Pulmonary drug delivery of antimicrobials and anticancer drugs using solid dispersions

Al-Obaidi, H. ORCID: https://orcid.org/0000-0001-9735-0303, Granger, A., Hibbard, T. and Opesanwo, S. (2021) Pulmonary drug delivery of antimicrobials and anticancer drugs using solid dispersions. Pharmaceutics, 13 (7). 1056. ISSN 1999-4923 doi: 10.3390/pharmaceutics13071056

Abstract/Summary

It is well established that currently available inhaled drug formulations are associated with extremely low lung deposition. Currently available technologies alleviate this low deposition problem via mixing the drug with inert larger particles, such as lactose monohydrate. Those inert particles are retained in the inhalation device or impacted in the throat and swallowed, allowing the smaller drug particles to continue their journey towards the lungs. While this seems like a practical approach, in some formulations, the ratio between the carrier to drug particles can be as much as 30 to 1. This limitation becomes more critical when treating lung conditions that inherently require large doses of the drug, such as antibiotics and antivirals that treat lung infections and anticancer drugs. The focus of this review article is to review the recent advancements in carrier free technologies that are based on coamorphous solid dispersions and cocrystals that can improve flow properties, and help with delivering larger doses of the drug to the lungs.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/99414
Identification Number/DOI	10.3390/pharmaceutics13071056
Refereed	No
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Optical Spectroscopy (CAF) Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Thermal Analysis (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Pharmaceutics Research Group
Publisher	MDPI
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