Intrinsic disorder prediction from the analysis of multiple protein fold recognition models

McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767 (2008) Intrinsic disorder prediction from the analysis of multiple protein fold recognition models. Bioinformatics, 24 (16). pp. 1798-1804. ISSN 1367-4803 doi: 10.1093/bioinformatics/btn326

Abstract/Summary

Motivation: Intrinsic protein disorder is functionally implicated in numerous biological roles and is, therefore, ubiquitous in proteins from all three kingdoms of life. Determining the disordered regions in proteins presents a challenge for experimental methods and so recently there has been much focus on the development of improved predictive methods. In this article, a novel technique for disorder prediction, called DISOclust, is described, which is based on the analysis of multiple protein fold recognition models. The DISOclust method is rigorously benchmarked against the top.ve methods from the CASP7 experiment. In addition, the optimal consensus of the tested methods is determined and the added value from each method is quantified. Results: The DISOclust method is shown to add the most value to a simple consensus of methods, even in the absence of target sequence homology to known structures. A simple consensus of methods that includes DISOclust can significantly outperform all of the previous individual methods tested.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/9849
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Biological Sciences Interdisciplinary centres and themes > Institute for Cardiovascular and Metabolic Research (ICMR)
Uncontrolled Keywords	QUALITY ASSESSMENT, DATABASE, REGIONS, SERVER
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