Immunogenetics of drug-induced skin blistering disorders. Part II: Synthesis

Bowman, C. and Delrieu, O. (2009) Immunogenetics of drug-induced skin blistering disorders. Part II: Synthesis. Pharmacogenomics, 10 (5). pp. 779-816. ISSN 1462-2416 doi: 10.2217/pgs.09.23

Abstract/Summary

The overall immunopathogenesis relevant to a large series of disorders caused by a drug or its associated hyperimmune condition is discussed based upon examining the genetics of severe drug-induced bullous skin problems (sporadic idiosyncratic adverse events including Stevens-Johnson syndrome and Toxic epidermal necrolysis). New results from an exemplar study on shared precipitating and perpetuating inner causes with other related disease phenotypes including aphtous stomatitis, Behcets, erythema multiforme, Hashimoto's thyroiditis, pemphigus, periodic fevers, Sweet's syndrome and drug-induced multisystem hypersensitivity are presented. A call for a collaborative, wider demographic profiling and deeper immunotyping in suggested future work is made.