Genicular artEry embolizatioN in patiEnts with oSteoarthrItiS of the knee (GENESIS) using permanent microspheres: interim analysis

Little, M. W., Gibson, M., Briggs, J., Speirs, A., Yoong, P., Ariyanayagam, T., Davies, N., Tayton, E., Tavares, S., MacGill, S., McClaren, C. and Harrison, R. ORCID: https://orcid.org/0000-0003-3674-9622 (2021) Genicular artEry embolizatioN in patiEnts with oSteoarthrItiS of the knee (GENESIS) using permanent microspheres: interim analysis. Cardiovascular and Interventional Radiology, 44. pp. 931-940. ISSN 0174-1551 doi: 10.1007/s00270-020-02764-3

Abstract/Summary

Purpose: Planned interim analysis of GENESIS; a prospective pilot study investigating the role of genicular artery embolization (GAE) in patients with mild to moderate osteoarthritis of the knee using permanent microspheres. Methods: Thirty-eight patients, median age = 60 (45–83), attended for GAE using 100–300 lm permanent microspheres. All patients had mild to moderate knee OA, resistant to conservative treatments over 6 months. Knee MRI was performed at baseline, and 12 months, enabling semi-quantitative analysis using Whole-Organ Magnetic Resonance Imaging Score (WORMS). Knee Injury and Osteoarthritis Outcome Score (KOOS) and visual analogue scale (VAS) (0–100 mm) were completed at baseline, 6 weeks, 3 months (n = 32), and 1-year (n = 16). Adverse events were recorded prospectively. Results: Technical success of accessing and embolizing the target genicular arteries was 84%. Six patients were not embolized: four due to a presumed risk of non-target embolization, and two due to a lack of hyperaemic target. Mean VAS improved from 60 (SD = 20, 95% CI 53–66) at baseline to 36 (SD = 24, 95% CI 28–44) at 3 months (p\0.001) and 45 (SD = 30, 95% CI 30–60) at 1-year (p\0.05). All KOOS subscales showed a significant improvement at 6-weeks, 3-months, and 1-year follow-up, except function in daily living, which reached borderline significance (p = 0.06) at 1-year. Four patients experienced mild self-limiting skin discoloration over the embolized territory. One patient experienced a small self-limiting groin haematoma. WORMS scores at 1-year follow-up showed significant improvement in synovitis (p \0.05). There were no cases of osteonecrosis. Conclusion: GAE using permanent microspheres in patients with mild to moderate knee OA is safe, with potential efficacy at early follow-up.

Additional Information	There is a correction to this article, published on 21/4/21, please see https://doi.org/10.1007/s00270-021-02849-7
Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/95642
Identification Number/DOI	10.1007/s00270-020-02764-3
Refereed	Yes
Divisions	Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN) Life Sciences > School of Psychology and Clinical Language Sciences > Department of Psychology Interdisciplinary centres and themes > Health Innovation Partnership (HIP)
Additional Information	There is a correction to this article, published on 21/4/21, please see https://doi.org/10.1007/s00270-021-02849-7
Publisher	Springer
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