Palmitoylethanolamide and related ALIAmides: prohomeostatic pipid compounds for animal health and wellbeing

Gugliandolo, E. ORCID: https://orcid.org/0000-0001-6840-3154, Peritore, A. F. ORCID: https://orcid.org/0000-0001-8545-990X, Piras, C. ORCID: https://orcid.org/0000-0002-6109-0834, Cuzzocrea, S. ORCID: https://orcid.org/0000-0001-6131-3690 and Crupi, R. ORCID: https://orcid.org/0000-0002-7629-3132 (2020) Palmitoylethanolamide and related ALIAmides: prohomeostatic pipid compounds for animal health and wellbeing. Veterinary Sciences, 7 (2). 78. ISSN 2306-7381 doi: 10.3390/vetsci7020078

Abstract/Summary

Virtually every cellular process is affected by diet and this represents the foundation of dietary management to a variety of small animal disorders. Special attention is currently being paid to a family of naturally occurring lipid amides acting through the so-called autacoid local injury antagonism, i.e., the ALIA mechanism. The parent molecule of ALIAmides, palmitoyl ethanolamide (PEA), has being known since the 1950s as a nutritional factor with protective properties. Since then, PEA has been isolated from a variety of plant and animal food sources and its proresolving function in the mammalian body has been increasingly investigated. The discovery of the close interconnection between ALIAmides and the endocannabinoid system has greatly stimulated research efforts in this field. The multitarget and highly redundant mechanisms through which PEA exerts prohomeostatic functions fully breaks with the classical pharmacology view of “one drug, one target, one disease”, opening a new era in the management of animals’ health, i.e., an according-to-nature biomodulation of body responses to different stimuli and injury. The present review focuses on the direct and indirect endocannabinoid receptor agonism by PEA and its analogues and also targets the main findings from experimental and clinical studies on ALIAmides in animal health and wellbeing.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/91332
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Uncontrolled Keywords	palmitoylethanolamide PEA, ALIAmides, autacoid local injury antagonism, endocannabinoid, wellbeing
Publisher	MDPI
Download/View statistics	View download statistics for this item