A nutrigenetic approach to investigate the relationship between metabolic traits and vitamin D status in an Asian Indian population

Alathari, B. E., Bodhini, D., Jayashri, R., Lakshmipriya, N., Rani, C. S. S., Sudha, V., Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455, Anjana, R. M., Mohan, V., Radha, V., Pradeepa, R. and Vimaleswaran, K. S. ORCID: https://orcid.org/0000-0002-8485-8930 (2020) A nutrigenetic approach to investigate the relationship between metabolic traits and vitamin D status in an Asian Indian population. Nutrients, 12 (5). 1357. ISSN 2072-6643 doi: 10.3390/nu12051357

Abstract/Summary

Studies in Asian Indians have examined the association of metabolic traits with vitamin D status. However, findings have been quite inconsistent. Hence, we aimed to explore the relationship between metabolic traits and 25-hydroxyvitamin D [25(OH)D] concentrations. We investigate whether this relationship was modified by lifestyle factors using a nutrigenetic approach in 545 Asian Indians randomly selected from the Chennai Urban Rural Epidemiology Study (219 normal glucose tolerant individuals, 151 with pre-diabetes and 175 individuals with type 2 diabetes). A metabolic genetic risk score (GRS) was developed using five common metabolic disease-related genetic variants. There was a significant interaction between metabolic GRS and carbohydrate intake (energy%) on 25(OH)D (Pinteraction = 0.047). Individuals consuming a low carbohydrate diet (≤62%) and those having lesser number of metabolic risk alleles (GRS ≤ 1) had significantly higher levels of 25(OH)D (p = 0.033). Conversely, individuals consuming a high carbohydrate diet despite having lesser number of risk alleles did not show a significant increase in 25(OH)D (p = 0.662). In summary, our findings show that individuals carrying a smaller number of metabolic risk alleles are likely to have higher 25(OH)D levels if they consume a low carbohydrate diet. These data support the current dietary carbohydrate recommendations of 50%–60% energy suggesting that reduced metabolic genetic risk increases 25(OH)D.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/90765
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Publisher	MDPI
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