Model self-assembling arginine-based tripeptides show selective activity against Pseudomonas bacteria

Castelletto, V., Edwards-Gayle, C. J. C., Hamley, I. W. ORCID: https://orcid.org/0000-0002-4549-0926, Barrett, G. ORCID: https://orcid.org/0000-0003-1509-0179, Seitsonen, J., Ruokolainen, J., de Mello, L. R. and da Silva, E. R. (2020) Model self-assembling arginine-based tripeptides show selective activity against Pseudomonas bacteria. Chemical Communications, 56. pp. 615-618. ISSN 1364-548X doi: 10.1039/c9cc07257h

Abstract/Summary

Three model arginine-rich tripeptides RXR (X = W, F or non-natural residue 2-napthylalanine) were investigated as antimicrobial agents, with a specific focus to target Pseudomonas aeruginosa through membrane lysis. Activity against biofilms was related to binding of the second messenger molecule, nucleotide bis-(30-50)-cyclic dimeric guanosine monophosphate (c-di-GMP). Strong selective activity against P. aeruginosa in planktonic form was observed for RFR and RWR.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/88113
Item Type	Article
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
Uncontrolled Keywords	Materials Chemistry, Electronic, Optical and Magnetic Materials, General Chemistry, Surfaces, Coatings and Films, Metals and Alloys, Ceramics and Composites, Catalysis
Publisher	Royal Society of Chemistry (RSC)
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