Inulin-fortification of a processed meat product attenuates formation of nitroso compounds in the gut of healthy rats

Thøgersen, R., Gray, N., Kuhnle, G. ORCID: https://orcid.org/0000-0002-8081-8931, Van Hecke, T., De Smet, S., Young, J. F., Sundekilde, U. K., Hansen, A. K. and Bertram, H. C. (2019) Inulin-fortification of a processed meat product attenuates formation of nitroso compounds in the gut of healthy rats. Food Chemistry, 302. 125339. ISSN 03088146 doi: 10.1016/j.foodchem.2019.125339

Abstract/Summary

Intake of red and processed meat has been suspected to increase colorectal cancer risk potentially via endogenous formation of carcinogenic N-nitroso compounds or increased lipid and protein oxidation. Here we investigated the effect of inulin fortification of a pork sausage on these parameters. For four weeks, healthy Sprague-Dawley rats (n = 30) were fed one of three diets: inulin-fortified pork sausage, control pork sausage or a standard chow diet. Fecal content of apparent total N-nitroso compounds (ATNC), nitrosothiols and nitrosyl iron compounds (FeNO) were analyzed in addition to liver metabolism and oxidation products formed in liver, plasma and diets. Intriguingly, inulin fortification reduced fecal ATNC (p = 0.03) and FeNO (p = 0.04) concentrations. The study revealed that inulin fortification of processed meat could be a strategy to reduce nitroso compounds formed endogenously after consumption

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/85569
Identification Number/DOI	10.1016/j.foodchem.2019.125339
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
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