Three thymine/adenine binding modes of the ruthenium complex Λ-[Ru (TAP)2(dppz)]2+ to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography

McQuaid, K. ORCID: https://orcid.org/0000-0002-3222-5584, Hall, J. P. ORCID: https://orcid.org/0000-0003-3716-4378, Baumgaertner, L., Cardin, D. J. and Cardin, C. J. ORCID: https://orcid.org/0000-0002-2556-9995 (2019) Three thymine/adenine binding modes of the ruthenium complex Λ-[Ru (TAP)2(dppz)]2+ to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography. Chemical Communications, 55. pp. 9116-9119. ISSN 1359-7345 doi: 10.1039/C9CC04316K

Abstract/Summary

Λ-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, the complex is not in contact with any G-quartet surface, even though there are four unique binding sites. Two complexes stabilise cavities formed from terminal TA and TT mismatched pairs. A third shows kinking by a TAP ligand between TT linkages, while the fourth shows intercalation of a dppz ligand at a TT/TA step stabilised by an additional T stacking interaction. Overall, the structure shows an unexpected affinity for thymine, and suggests models for G-quadruplex loop binding.

Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/84918
Identification Number/DOI	10.1039/C9CC04316K
Refereed	Yes
Divisions	Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry Interdisciplinary centres and themes > Chemical Analysis Facility (CAF) > Xray (CAF) Life Sciences > School of Chemistry, Food and Pharmacy > School of Pharmacy > Medicinal Chemistry Research Group
Publisher	The Royal Society of Chemistry
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