CACHD1: a new activity-modifying protein for voltage-gated calcium channels

Downloads

1. Zamponi, G. W., Striessnig, J., Koschak, A., and Dolphin, A. C. (2015) The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential. Pharmacol Rev 67, 821-870 2. Dolphin, A. C. (2012) Calcium channel auxiliary alpha2delta and beta subunits: trafficking and one step beyond. Nat Rev Neurosci 13, 542-555 3. Cottrell, G. S., Soubrane, C. H., Hounshell, J. A., Lin, H., Owenson, V., Rigby, M., Cox, P. J., Barker, B. S., Ottolini, M., Ince, S., Bauer, C. C., Perez-Reyes, E., Patel, M. K., Stevens, E. B., and Stephens, G. J. (2018) CACHD1 is an alpha2delta-like protein that modulates CaV3 voltage-gated calcium channel activity. J Neurosci 38, 9186-9201 4. Weiss, N., and Zamponi, G. W. (2019) T-type calcium channels: From molecule to therapeutic opportunities. Int J Biochem Cell Biol 108, 34-39 5. Dahimene, S., Page, K. M., Kadurin, I., Ferron, L., Ho, D. Y., Powell, G. T., Pratt, W. S., Wilson, S. W., and Dolphin, A. C. (2018) The alpha2delta-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with alpha2delta-1. Cell Rep 25, 1610-1621 e1615 6. Soubrane, C. H., Stevens, E. B., and Stephens, G. J. (2012) Expression and functional studies of the novel CNS protein CACHD1. Proceedings of The Physiological Society 27, PC74 7. Whittaker, C. A., and Hynes, R. O. (2002) Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Mol Biol Cell 13, 3369-3387 8. Anantharaman, V., and Aravind, L. (2000) Cache - a signaling domain common to animal Ca2+-channel subunits and a class of prokaryotic chemotaxis receptors. Trends Biochem Sci 25, 535-537 9. Wu, J., Yan, Z., Li, Z., Qian, X., Lu, S., Dong, M., Zhou, Q., and Yan, N. (2016) Structure of the voltage-gated calcium channel CaV1.1 at 3.6 A resolution. Nature 537, 191-196 10. Ray, P., Torck, A., Quigley, L., Wangzhou, A., Neiman, M., Rao, C., Lam, T., Kim, J. Y., Kim, T. H., Zhang, M. Q., Dussor, G., and Price, T. J. (2018) Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research. Pain 159, 1325-1345