The effects of flavonoids on cardiovascular health: a review of human intervention trials and implications for cerebrovascular function

Rees, A., Dodd, G. F. and Spencer, J. P. E. ORCID: https://orcid.org/0000-0003-2931-7274 (2018) The effects of flavonoids on cardiovascular health: a review of human intervention trials and implications for cerebrovascular function. Nutrients, 10 (12). 1852. ISSN 2072-6643 doi: 10.3390/nu10121852

Abstract/Summary

Research has suggested a number of beneficial effects arising from the consumption of dietary flavonoids, found in foods such as cocoa, apples, tea, citrus fruits and berries on cardiovascular risk factors such as high blood pressure and endothelial dysfunction. These effects are thought to have a significant impact upon both vascular and cerebrovascular health, ultimately with the potential to prevent cardiovascular and potentially neurodegenerative disease with a vascular component, for example vascular dementia. This review explores the current evidence for the effects of flavonoid supplementation on human endothelial function and both peripheral and cerebral blood flow (CBF). Evidence presented includes their potential to reduce blood pressure in hypertensive individuals, as well as increasing peripheral blood perfusion and promoting CBF in both healthy and at-risk populations. However, there is great variation in the literature due to the heterogeneous nature of the randomised controlled trials conducted. As such, there is a clear need for further research and understanding within this area in order to maximise potential health benefits.

Additional Information	This article belongs to the Special Issue 'Flavonoid Intake and Human Health'.
Item Type	Article
URI	https://reading-clone.eprints-hosting.org/id/eprint/80967
Identification Number/DOI	10.3390/nu10121852
Refereed	Yes
Divisions	Life Sciences > School of Chemistry, Food and Pharmacy > Department of Food and Nutritional Sciences > Human Nutrition Research Group
Additional Information	This article belongs to the Special Issue 'Flavonoid Intake and Human Health'.
Publisher	MDPI
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